Sang-Cheol Bae

• 2019 연구우수교수

Profile

• 2019-present Director, Hanyang University Institute for Rheumatology Research, Seoul, Korea
• 2018-present Editorial Board, Annals of Rheumatic Diseases
• 2018-present Vice President, Korean Academy of Medical Sciences
• 2018-present Full member, Korean Academy of Science and Technology
• 2016-present Full member, APLC (Asia Pacific Lupus Collaboration)
• 2016-present President, Korean Society of Systemic Lupus Erythematosus Erythematosus Research
• 2011-present Full member, National Academy of Medicine of Korea
• 2008-2015 Clinical Research Center for Rheumatoid Arthritis by Ministry of Health and Welfare, Korea (PI, Director)
• 2006-2007 Presidential Medical R&D advisory committee member
• 2005-2019 Director, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea
• 1998-present Full member, SLICC (Systemic Lupus International Collaborating Clinics)
• 1997-1998 Ad hoc Committee on Neuropsychiatric SLE nomenclature (co-chair)
• 1996-1998 Research Fellow and Instructor, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA
• 1993-present Professor in Internal Medicine, Rheumatology, Hanyang University, Seoul, Korea
• 2012-present Hanyang University Distinguished Professor, Seoul, Korea
• 1996-1998 MPH, School of Public Health, Harvard University, Boston, MA, USA
• 1985-1993 PhD (Medicine), Hanyang University, Seoul, Korea
• 1978-1984 MD, College of Medicine, Hanyang University, Seoul, Korea

Throughout his illustrious career, Professor Bae has been honoured with numerous academic awards, including the 2008 Distinguished Clinical Investigator Award by the Asia Pacific League of Associations for Rheumatology, 2010 Hanmi Proud Doctor Award by the Korean Medical Association, 2011 Korean Rheumatology Academic Award by the Korean College of Rheumatology, 2012 Hanyang University Distinguished Scholar Professor award, 2016 Minister of Health & Welfare Award, 2017 National R&D Excellence Award by Minister of Science and ICT, 2018 Wunsch Medical Award by the Korean Academy of Medical Sciences, and 2019 Paiknam Distinguished Scholar Professor award by Hanyang University.

Research Topics

In the field of rheumatic diseases, particularly rheumatoid arthritis [RA] and systemic lupus erythematosus [SLE],

• Clinical Epidemiology including clinimetrics, clinical trials and innovative treatment development, clinical and pharmaco-economics, and outcomes research
• Genetic Epidemiology including drug discovery and repurposing
• Precision Medicine

Prof Bae’s research has the overall theme of understanding clinical, environmental & genetic factors associated with rheumatic diseases (RA and SLE) and their individual prognosis and drug response prediction for the precision medicine. For this purpose, as one of the most prominent clinician and researchers in Asia in this field, he has established large Korean RA & SLE cohorts, solved clinically important questions, and identified clinical predictors and dozens of common genetic variants and epidemiologic factors conferring risk of the diseases using the advanced methodology like GWAS, NGS, immunochip and HLA imputation for multiple ancestral populations. With these studies, he has also discovered novel biologic insights and therapeutic targets which implicate a potential guiding role of human RA/SLE genetics data in drug discovery and repurposing. He has successfully administered and participated in many multinational and multicenter projects as a principal investigator and co-investigator and he is always well aware of the factors needed for a successful research project which he will carry out.

Papers

He has published ~700 articles on these topics in national and international peer-reviewed journals including, Nature, Nature Genetics, Nature communications, American Journal of Human Genetics, PLoS genetics, Annals of the Rheumatic Diseases, Arthritis and Rheumatology, Human Molecular Genetics, and Rheumatology, to name a few. Selected articles are as follows.

• “Trial Investigators. Trial of Anifrolumab in Active Systemic Lupus Erythematosus”, N Engl J Med., 2020 https://www.nejm.org/doi/pdf/10.1056/NEJMoa1912196

• “Deletion at 2q14.3 is associated with worse response to TNF-α blockers in patients with rheumatoid arthritis”, Arthritis Res Ther, 2019 https://link.springer.com/article/10.1186/s13075-019-1983-y

• “Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians”, PLoS Genet, 2019 https://journals.plos.org/plosgenetics/article?rev=2&id=10.1371/journal.pgen.1008092

• “Biological function integrated prediction of severe radiographic progression in rheumatoid arthritis: a nested case control study”, Arthritis Res Ther, 2017 https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-017-1414-x

• “Influence of HLA-DRB1 Susceptibility alleles on the clinical subphenotypes of Systemic Lupus Erythematosus in Koreans”, Arthritis Rheumatol, 2016 https://onlinelibrary.wiley.com/doi/full/10.1002/art.39539

• “Identification of a systemic lupus erythematosus risk locus spanning ATG16L2, FCHSD2, and P2RY2 in Koreans”, Arthritis Rheumatol, 2016 https://onlinelibrary.wiley.com/doi/full/10.1002/art.39548

• “High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry”, Nat Genet, 2016 https://www.nature.com/articles/ng.3496

• “Interactions between amino-acid-defined MHC class II variants and smoking for seropositive rheumatoid arthritis“, Arthritis Rheumatol, 2015 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581918/

• “High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci”, Ann Rheum Dis., 2015 https://ard.bmj.com/content/74/3/e13.short

• “Genetics of rheumatoid arthritis contributes to biology and drug discovery”, Nature, 2014 https://www.nature.com/articles/nature12873

• “The HLA* DRβ1 amino acid positions 11-13-26 explain the majority of SLE-MHC associations”, Nat Commun, 2014 https://www.nature.com/articles/ncomms6902

• “Smoking, the HLA-DRB1 shared epitope and ACPA fine-specificity in Koreans with rheumatoid arthritis: evidence for more than one pathogenic pathway linking smoking to disease”, Ann Rheum Dis, 2014 https://ard.bmj.com/content/73/4/741.short

• “Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries”, Ann Rheum Dis, 2012 https://ard.bmj.com/content/71/11/1809.short

• “Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status”, Arthritis Rheum, 2010 https://onlinelibrary.wiley.com/doi/full/10.1002/art.27272

• “Increased Susceptibility to Rheumatoid Arthritis in Koreans Heterozygous for HLA-DRB1*0405 and *0901” Arthritis Rheum, 2004 https://onlinelibrary.wiley.com/doi/full/10.1002/art.20608

Contact Information

• E-mail : scbae@hanyang.ac.kr